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The effect of pulmonary edema on gas trapping in excised rat lungs.

Authors
Frazer-DG; Stengel-PW; Weber-KC
Source
Respir Physiol 1979 Dec; 38(3):325-333
NIOSHTIC No.
00118204
Abstract
The relationship between gas trapping in excised rat lungs and pulmonary edema was studied. Pulmonary edema was induced in male Long-Evans-rats by means of high inspiratory positive pressure breathing. The lungs were then inflated and deflated for six different sequences of four cycles each. Deflation was at an end expiratory pressure of positive 6, 4, 3, 2, 0, or negative 5 centimeters of water. The volume of gas trapped in the lungs was measured. Lungs with pulmonary edema trapped gas at more positive values of end expiratory pressure than normal lungs. The authors conclude that at more positive transpulmonary pressures, the airways in excised lungs close sooner than those in normal lungs.
Keywords
NIOSH-Author; Lung-cancer; Laboratory-animals; Pulmonary-function; Respiratory-gas-analysis; Respiratory-gas-transport; Respiratory-gases; Author Keywords: Airway closure; Excised rat lungs; Foam in lungs; Lung pressure-volume curves; Meniscus formation in airways
CODEN
RSPYAK
Publication Date
19791201
Document Type
Journal Article
Fiscal Year
1980
NTIS Accession No.
NTIS Price
Issue of Publication
3
ISSN
0034-5687
NIOSH Division
ALOSH
Source Name
Respiration Physiology
State
WV
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