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Lack of prenatal effects of maternal ethanol consumption in CD-1 mice.

Authors
Hood-RD; Lary-JM; Blacklock-JB
Source
Toxicol Lett 1979 Aug; 4(2):79-82
NIOSHTIC No.
00117461
Abstract
The effects of alcohol in prenatal exposure in CD-1-mice were investigated and an experimental protocol for the fetal alcohol syndrome (FAS) was evaluated. Pregnant mice received 20 percent ethanol (64175) in their drinking water on days 1 to 11, 6 to 11, or 7 to 11 of gestation, or 10 percent ethanol on days 2 to 11 of gestation. Fetuses were removed for examination on day 18. Fluid consumption of ethanol groups was less than that of controls but no difference was found in hematocrits. Ethanol treatment did not affect fetal mortality, weight, or development. The authors conclude that the protocol employed is not suitable for producing an overt FAS. They suggest that researchers interested in using the mouse as an animal model of FAS consider the influence of mouse strain and treatment protocol on test outcome.
Keywords
NIOSH-Author; Laboratory-animals; Alcohols; Toxicology; Reproductive-effects; Growth-factors; Analytical-methods; Models; Medical-research
CODEN
TOLED5
CAS No.
64-17-5
Publication Date
19790701
Document Type
Journal Article
Fiscal Year
1979
NTIS Accession No.
NTIS Price
Issue of Publication
2
ISSN
0378-4274
Source Name
Toxicology Letters
State
AL
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