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Volcanic ash and human complement.

Authors
Olenchock-SA; Mull-JC
Source
Life Sci 1981 Feb; 28(7):791-794
NIOSHTIC No.
00115798
Abstract
The effects of volcanic ash on the human complement cascade were investigated. Dusts from Mount Saint Helens, ground silica, and airborne grain dusts were added to normal human serum. Serum was tested for complement activation and monitored by electrophoresis. Factor-B was not converted at any concentration of volcanic ash. Human complement component C3 was converted to C3b by volcanic ash and silica dusts, but only moderately when compared to conversions activated by grain dusts. The activation of C3 by volcanic ash had little effect on the human complement cascade. The authors conclude that even barely detectable consumption of complement can activate significant biological activity.
Keywords
NIOSH-Author; Combustion-products; Biological-effects; Biochemistry; Hematology; Humans; Biochemical-analysis; Immunology
CODEN
LIFSAK
Publication Date
19810201
Document Type
Journal Article
Fiscal Year
1981
NTIS Accession No.
NTIS Price
Issue of Publication
7
NIOSH Division
DRDS
Source Name
Life Sciences
State
WV
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