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Recent morphological studies of toxic neuropathy.

Authors
Spencer-PS; Schaumburg-HH
Source
Mechanisms of Toxicity and Hazard Evaluation: Proceedings of the Second International Congress on Toxicology held in Brussels, Belgium, July 6-11, 1980. Holmstedt B, ed., New York: Elsevier, 1980 Jul; :3-11
Link
NIOSHTIC No.
00115796
Abstract
Studies of toxic neuropathy are reviewed. The grouping of the heterogeneous collection of neuropathies into neuronopathy, axonopathy, and myelinopathy is discussed. Techniques are outlined for the preparation and examination of peripheral nervous tissue in animals. The use of organotypic tissue cultures is discussed. The differences between pathological and spontaneous changes, preparative artifacts, or age related changes are described along with types of cellular responses to neurotoxic compounds. Toxic neuropathies are defined together with symptoms and chemicals that affect each. The different cellular targets of various neurotoxic chemicals are discussed. The authors conclude that nosology of toxic neuropathies is useful in predicting patterns of dysfunction and in designing appropriate tests to detect subclinical deficits. It also facilitates identification of a particular organelle or system that may be affected by the toxin.
Keywords
NIOSH-Grant; Nervous-system-disorders; Analytical-methods; Cellular-reactions; Toxins; Neurotoxins; Morphology; Neurotoxicity; Toxicology
Contact
Pathology Albert Einstein Coll of Med 1300 Morris Park Avenue Bronx, N Y 10461
Publication Date
19800701
Document Type
Conference/Symposia Proceedings
Editors
Holmstedt-B
Funding Amount
807725
Funding Type
Grant
Fiscal Year
1980
NTIS Accession No.
NTIS Price
ISBN No.
9780444802934
Identifying No.
Grant-Number-R01-OH-00535
Source Name
Mechanisms of Toxicity and Hazard Evaluation: Proceedings of the Second International Congress on Toxicology held in Brussels, Belgium, July 6-11, 1980
State
NY
Performing Organization
Yeshiva University, New York, New York
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