Chromosome aberrations as a biological dose-response indicator of radiation exposure in uranium miners.
Brandom-WF; Saccomanno-G; Archer-VE; Archer-PG; Bloom-A
Radiat Res 1978 Jan; 76:159-171
The relationship between radiation exposure and chromosome aberrations was studied in uranium miners (SIC-1094). Peripheral blood lymphocytes from 80 uranium miners and 20 unexposed workers were cultured and analyzed for structural chromosomal aberrations. Miners were classified into five exposure groups according to exposure estimates based on mine air measurements and underground work time. The prevalence of all types of structural chromosomal aberrations except dicentrics plus rings was significantly higher among all groups of miners than among unexposed subjects. All aberration categories except dicentrics plus rings increased in frequency with increasing dose for workers exposed up to 2890 working level months (WLM). All aberrations except inversions plus translocations were less prevalent in workers exposed for more than 3000WLM than in workers exposed 700 to 2890WLM. The most persistent pattern of aberration increases with increasing dose occurred in the pericentric inversions plus translocations grouping. Miners with markedly atypical cells had a higher proportion of chromosomal aberrations and two hit aberrations than miners with normal or mild to moderate atypical cells. The authors conclude that except for dicentrics plus rings the prevalence of chromosome aberrations is a sensitive biological indicator of low level irradiation among uranium miners.
NIOSH-Author; Radioactive-heavy-metals; Mine-workers; Hematology; Health-surveys; Genetic-disorders; Chromosome-damage; Dose-response; Radiation-hazards