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Effect of dietary intake of lead acetate on copper metabolism in male rats.

Authors
Klauder-DS; Murthy-L; Petering-HG
Source
Trace Subst Environ Health 1973 Jan; 6:131-136
Link
NIOSHTIC No.
00113660
Abstract
The effect of lead (7439921) on copper (7440508) metabolism was investigated. Male Sprague-Dawley-rats were fed diets ranging in copper content from 0.5 to 2.5 micrograms per day. Fifty percent of the animals also received a diet containing 0.5 percent lead. During the 8 week experimental period, food and water intakes were periodically monitored and blood and urine samples were collected. Lead treated animals had growth retardation. There were negligible differences in food and water intakes. Lead inhibition was inversely related to dietary copper amounts. Lead treated animals had 15 to 20 times more lead in the urine than controls. Ceruloplasmin concentrations, a reliable measurement of copper metabolism, in lead exposed animals were markedly lower compared to controls. Erythrocyte lead concentrations decreased as the dietary copper increased. The authors conclude that one of the toxic effects of lead is to adversely change copper metabolism.
Keywords
NIOSH-Publication; NIOSH-Grant; Stokinger; Toxicology; Heavy-metals; Metabolism; Laboratory-animals; Lead-compounds; Growth-factors
Contact
Environmental Health Kettering Laboratory Eden & Bethesda Avenues Cincinnati, Ohio 45219
CODEN
PUMTAG
CAS No.
7439-92-1; 7440-50-8
Publication Date
19730101
Document Type
Journal Article
Funding Amount
311966.00
Funding Type
Grant
Fiscal Year
1973
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00337
ISSN
0361-5162
Source Name
Trace Substances in Environmental Health
State
OH
Performing Organization
University of Cincinnati, Cincinnati, Ohio
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