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Precipitation of serum proteins by extracts of cotton dust and stems : identification of -lipoprotein and production of specific antibodies.

Authors
Kutz-SA; Mentnech-MS; Olenchock-SA; Major-PC
Source
Environ Res 1980 Aug; 22(2):476-484
NIOSHTIC No.
00112381
Abstract
Serum proteins reacting with a pseudoimmune precipitating agent found in cardroom cotton dust and cotton stem material were identified. Specimen particles were ground and extracted separately at 4 degrees C and the supernatant fluids were sterilized and concentrated 40 fold. Antisera to cotton bracts and leaves were developed in rabbits. Human and rabbit sera were examined for immune and pseudoimmune precipitation, and sera from normal human subjects, cotton textile workers and a serum preparation lacking beta-lipoprotein were separately mixed with either the cotton dust or stem extract, incubated and centrifuged. No true precipitating antibodies to extracts of cotton bracts, carpels, stems, leaves, immature cotton lint, or cardroom cotton dust were found in the 59 human sera samples. Precipitating antibodies were produced in the rabbit immunization test. The authors note that the plant agent responsible for precipitation of the beta-lipoprotein and gamma globulin was suspected to be a polyphenic tannin.
Keywords
NIOSH-Author; Immunology; Cotton-dusts; Textiles; Allergic-reactions; Hematology
CODEN
ENVRAL
Publication Date
19800801
Document Type
Journal Article
Fiscal Year
1980
NTIS Accession No.
NTIS Price
Issue of Publication
2
ISSN
0013-9351
NIOSH Division
DRDS
Source Name
Environmental Research
State
WV
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