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Toxic mechanisms of inhaled methyl methacrylate vapor.

Authors
Tansy-MF
Source
Department of Physiology and Biophysics, Temple University School of Dentistry, Philadelphia, Pennsylvania 1979 Feb; :1-4
Link
NIOSHTIC No.
00112356
Abstract
The toxic effects of inhaled methyl-methacrylate (80626) (MMA) vapor in Sprague-Dawley-rats were studied. Animals inhaled 116 parts per million (ppm) of MMA 8 hours daily, 5 days a week, for 45 or 90 days. Body weight, daily food intake, fecal fat content, intestinal absorption, plasma lipid concentration, and tissue fat concentrations were measured at various intervals. Ninety day inhalation of MMA affected tissue weight, blood chemistry, metabolic behavior, and hepatic and ciliary function in rats, but did not depress body weight or epididymal or popliteal fat pad weight. MMA also produced gastrointestinal motor inhibition and histological evidence of liver damage. The LC50 for rats inhaling MMA was 7093ppm; death was caused by respiratory failure. The author concludes that MMA inhibits gastrointestinal contractility and hepatic metabolism. He notes that preliminary research with other volatile acrylates such as ethyl-acrylate and butyl-acrylate shows that these compounds have effects similar to those for MMA.
Keywords
NIOSH-Grant; Grants-other; Biochemistry; Physiology; Laboratory-animals; Histology; Metabolism; Reaction-rates
Contact
Physiology and Biophysics Temple University 3223 N Broad Street Philadelphia, PA 19140
CAS No.
80-62-6
Publication Date
19790221
Document Type
Final Grant Report
Funding Amount
78696
Funding Type
Grant
Fiscal Year
1979
NTIS Accession No.
PB88-252663
NTIS Price
A01
Identifying No.
Grant-Number-R01-OH-00518
NIOSH Division
OEP
Priority Area
Other Occupational Concerns; Grants-other
Source Name
Department of Physiology and Biophysics, Temple University School of Dentistry, Philadelphia, Pennsylvania
State
PA
Performing Organization
Temple University, Philadelphia, Pennsylvania
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