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Etiology of disc degeneration relation to low back pain.

Authors
Smith-SD; Lafferty-JF; Winter-WG
Source
NIOSH 1979 Aug; :1-8
Link
NIOSHTIC No.
00112321
Abstract
The etiology of disc degeneration related to low back pain was studied in Macaca-mulatta or Cynomologus-iris-monkeys. Pieces of surgical tubing were implanted between vertebrae to compress the vertebral disc for 90 days, and the lumbar spine was then examined. Some of the experimental animals were also injected with tracers to determine diffusion from the disc and protein metabolism, and intradisc pressure was measured in other experimental animals. Pressures greater than 0.46 kilograms per square centimeter on the disc produced progressive loss of the fibrocellular interface between disc and endplate, and a progressive and significant compression of the endplate. Equivalent pressure on the annulus fibrosis region caused loss of polysaccharide and nuclear herniation in six animals. Compressed disc endplates showed a marked increase in pyknotic chondrocytes. No difference in control disc and compressed disc diffusion rate occurred, but compressed discs did not incorporate labeled material uniformly or well; hyaline endplate and annulus cells were almost devoid of labeling. Compressed disc did not incorporate proline, demonstrating marked interference with protein metabolism. Immediately after surgical banding, pressure in the compressed disc rose to 1500 millimeters of mercury, but pressure returned to normal within 30 minutes. The authors conclude that the monkey provides a good animal model of stress induced intervertebral disc degeneration, and that disc degeneration has morphological and physiological effects.
Keywords
NIOSH-Grant; Life-sciences; Back-injuries; Skeletal-system; Spinal-cord; Animal-studies; Models; Medical-research; Skeletal-system-disorders
Contact
Mechanical Engineering University of Kentucky Lexington, KY 40506 Lexington, KY 40506
Publication Date
19790831
Document Type
Final Grant Report
Funding Amount
178750
Funding Type
Grant
Fiscal Year
1979
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00562
NIOSH Division
OEP
Source Name
University of Kentucky, Lexington, Kentucky, NIOSH
State
KY
Performing Organization
University of Kentucky, Lexington, Kentucky
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