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Acute experimental pulmonary responses to cardroom cotton dust.

Authors
Kutz-SA; Mentnech-MS; Mull-JC; Olenchock-SA; Major-PC
Source
Arch Environ Health 1980 Sep; 35(4):205-210
NIOSHTIC No.
00112235
Abstract
The effect of cotton dust on pulmonary response was tested in female New-Zealand-White-rabbits. Baseline resting blood gas levels for each animal were determined. The animals were exposed to untreated cardroom cotton dust (BCD) aerosols for 1 hour per day, 4 days per week for 15 consecutive weeks. During the exposures, 500 milligrams of dust were added every 10 minutes at an air flow rate of 35 liters per minute. One week after the end of the BCD studies, four rabbits which had reacted to the BCD were subjected to a similar challenge with washed and lyophilized cotton dust (TCD). Both TCD and BCD were of similar particle size. At 1 hour post-exposure, significant decreases in arterial oxygen tension (PaO2) occurred which became progressively greater throughout the study. Increases in arterial carbon-dioxide (124389) tension (PaC02) were observed. The alveolar- arterial oxygen gradient (A-a) increased as the exposure regimen continued. No significant changes in Pa02, PaC02 or A-a were noted at 3 hours post-exposure, while at 5 and 24 hours significant decreases in PaO2 were seen. In rabbits exposed to TCD, the mean decrease of PaO2 at 1 hour post-exposure was about five times less than the mean decrease at 15 weeks of exposure to BCD. The 1 hour post-exposure A-a for the BCD exposure was three times greater than after TCD exposure. The authors conclude that BCD is a much more potent incident of respiratory pathophysiology than TCD.
Keywords
NIOSH-Author; Epidemiology; Cotton-dusts; Airborne-dusts; Air-contamination; Pulmonary-system-disorders; Workplace-studies; Laboratory-animals; Particulates; Blood-analysis
CODEN
AEHLAU
CAS No.
124-38-9
Publication Date
19800801
Document Type
Journal Article
Fiscal Year
1980
NTIS Accession No.
NTIS Price
Issue of Publication
4
ISSN
0003-9896
NIOSH Division
DRDS
Priority Area
Pulmonary-system-disorders
Source Name
Archives of Environmental Health
State
WV
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