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Effect of ozone on elastic behavior of excised lungs of dogs.

Authors
Frank-R; Flesch-JP; Brain-JD
Source
Environ Res 1971 Oct; 4(4):343-354
NIOSHTIC No.
00107851
Abstract
The effects of ozone (10028156) on lung elasticity were studied in mongrel dogs. Paired lung lobes were excised. One lobe was ventilated with filtered air for 3 hours, and the other was ventilated with filtered air for 30 minutes followed by ozone for 2.5 hours. A slight depression of the static volume pressure (P/V) relationship occurred in lobes exposed to 6.8 to 10.3 parts per million of ozone for 2.5 hours. Dynamic compliance decreased more rapidly in lobes ventilated with ozone. The authors note that depressed P/V occurred at ozone concentrations great enough to cause pulmonary edema and death in vivo. They conclude that ozone causes limited changes in the elastic behavior of excised lobes. They suggest that the primary cause of altered elastic behavior during short term exposure to ozone in vivo may be the occurrence of edema, severe changes in airway flow resistance, or shifts in lung volume.
Keywords
NIOSH-Publication; NIOSH-Grant; Toxic-effects; Oxidizers; Respiratory-irritants; Lung-function; Laboratory-animals; Pulmonary-system-disorders; Pulmonary-function; Elastic-properties
Contact
Preventive Medicine University of Washington Dept of Preventive Medicine Seattle, Wash 98105
CODEN
ENVRAL
CAS No.
10028-15-6
Publication Date
19711001
Document Type
Journal Article
Funding Amount
420211.00
Funding Type
Grant
Fiscal Year
1972
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00340
Issue of Publication
4
ISSN
0013-9351
Priority Area
Pulmonary-system-disorders
Source Name
Environmental Research
State
WA
Performing Organization
University of Washington, Seattle, Washington
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