Changes in LD50 of parathion and heptachlor following turpentine pretreatment.
Sperling-F; Ewenike-HK; Farber-T
Environ Res 1972 Jun; 5(2):164-171
The effect of turpentine (8006642) on sleep and the median lethal dose (LD50) of parathion (56382), and heptachlor (76448) was studied in male rats. Wistar-rats or Charles-River-rats were intubated once daily for 3 days with 1.8 milligrams per kilograms (mg/kg) of turpentine. On day 4, LD50s of parathion, paraoxon (311455), heptachlor or heptachlor-epoxide (1024573) were determined. Other rats were exposed to 3 to 4mg per liter of turpentine vapors for 6 hours per day for 3 days or to air. On day 4, the rats were orally given 50mg/kg parathion, 10mg/kg paraoxon, 80mg/kg heptachlor, or 80mg/kg heptachlor-epoxide. Rats from each group were injected intraperitoneally with 125mg/kg hexobarbital (50099) and sleep time was recorded. Pretreatment with oral turpentine reduced hexobarbital sleeping time and the LD50 of parathion, and increased heptachlor mortality. Hexobarbital hydroxylase, aminopyrene demethylase, benzpyrene hydroxylase and p-aminophenol aniline hydroxylase were stimulated. Alpha and beta pinene vaporized from turpentine increased heptachlor mortality and benzpyrene hydroxylation. The authors conclude that turpentine stimulates male rat microsomal enzymes. They suggest that pesticides might affect insects and wildlife differently depending on their environment.
NIOSH-Publication; NIOSH-Grant; Toxic-effects; Wood-products; Turpentines; Fumes; Median-lethal-dose; Chlorinated-hydrocarbon-insecticides; Enzyme-activity
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