Human Semen Assays for Workplace Monitoring.
NIOSH 1980 Oct:327-355
The use of semen analysis for monitoring worker exposures is evaluated. Assessment of sperm count, motility and morphology is discussed. Procedures are outlined for cross sectional and longitudinal studies, including population and donor selection, assignment to exposure group, sample collection and analysis, and statistical evaluation. Examples of both types of studies are provided and the effectiveness of each methodology is discussed. Semen abnormalities are reviewed in relation to genetic and fertility implications. The use of mouse models and their relation to human test results are described. Slow cytometry for DNA assessment is considered, and applications in mouse and human studies are described. The status of automated slide based scanning systems for human sperm analysis is reviewed. The authors conclude that sperm analysis techniques can be used in routine worker screening programs to identify agents that can cause adverse reproductive effects.
Medical-monitoring; Reproductive-effects; Occupational-exposure; Research; Teratogenesis;
Proceedings of a Workshop on Methodology for Assessing Reproductive Hazards in the Workplace, April 19-22, 1978, P.F. Infante and M.S. Legator, Eds. Division of Surveillance, Hazard Evaluations and Field Studies, NIOSH, U.S. Department of Health and Human Services