The use of cytogenic analysis for monitoring exposures in industrial populations is discussed. Considerations for data analysis are reviewed and results of previous cytogenic studies of workers exposed to benzene (71432) and epichlorohydrin (106898) are included. The author concludes that cytogenic analysis is a valuable exposure surveillance tool. At least 200 cells per person should be examined to establish an accurate chromosomal aberration profile. He notes that benzene and epichlorohydrin appear to produce cytogenic abnormalities in humans.
Proceedings of a Workshop on Methodology for Assessing Reproductive Hazards in the Workplace, April 19-22, 1978, P.F. Infante and M.S. Legator, Eds. Division of Surveillance, Hazard Evaluations and Field Studies, NIOSH, U.S. Department of Health and Human Services