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Genetic Toxicology--Relevant Studies with Animal and Human Subjects.

Authors
Legator-MS
Source
NIOSH 1980 Oct:261-273
Link
NIOSHTIC No.
00105782
Abstract
Laboratory animal and human mutagenicity testing is discussed. The limitations of in-vitro test procedures for extrapolation of risks to man are evaluated. The objectives of mutagenicity testing are reviewed, including risk establishment and quantification, and prediction of other biological effects. Experimental techniques used in animal testing are described based on induction of premutational lesions, point mutations and chromosomal changes. Cytogenic analysis, urinalysis for mutagen detection, sperm analysis for morphological changes, and Y-chromosome nondisjunction analysis are discussed as test procedures for studies in human subjects. The author recommends that in-vitro bacterial tests be used only in conjunction with more relevant in-vivo mutagenicity tests. Test batteries should be selected on the basis of their ability to cover all possible genetic lesions and metabolic products, reproducibility, and predictive value for human risk.
Keywords
Laboratory-animals; Humans; Genetics; Risk-factors; Research; Analytical-methods; In-vivo-study; In-vitro-study;
Publication Date
19801001
Fiscal Year
1981
NTIS Accession No.
NTIS Price
NIOSH Division
DSHEFS;
Source Name
Proceedings of a Workshop on Methodology for Assessing Reproductive Hazards in the Workplace, April 19-22, 1978, P.F. Infante and M.S. Legator, Eds. Division of Surveillance, Hazard Evaluations and Field Studies, NIOSH, U.S. Department of Health and Human Services
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