Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Incorporation of Perinatal Exposure Into Bioassays For Carcinogenicity.

Authors
Rice-JM
Source
NIOSH 1980 Oct:247-260
Link
NIOSHTIC No.
00105781
Abstract
Perinatal exposure schedules used in carcinogenicity tests are discussed. Conventional testing procedures are described based on species selection, test doses of the chemical, latency period, and statistical evaluation. Carcinogenic responses in the fetus, neonate and infant are reviewed in relation to susceptibility at that point of development. Considerations involved in incorporating perinatal exposures into standard carcinogenesis assays are evaluated, including exposure duration, the number of animals needed and dose selection. Criteria are presented for establishing the carcinogenicity of a chemical.
Keywords
Reproductive-effects; Embryotoxicity; Neonates;
Publication Date
19801001
Fiscal Year
1981
NTIS Accession No.
NTIS Price
NIOSH Division
DSHEFS;
Source Name
Proceedings of a Workshop on Methodology for Assessing Reproductive Hazards in the Workplace, April 19-22, 1978, P.F. Infante and M.S. Legator, Eds. Division of Surveillance, Hazard Evaluations and Field Studies, NIOSH, U.S. Department of Health and Human Services
TOP