The Role of Behavioral Assessment in Standard In Vivo Teratogenicity Testing.
NIOSH 1980 Oct:227-245
The use of behavioral changes as an indicator of teratogenic potential is evaluated. Testing procedures involving central nervous system activity or task specific responses are discussed along the effects of drug metabolism on behavioral response. Preliminary results of a behavioral teratology study of methylene- chloride (75092) in Long-Evans-rats are included. The author concludes that behavioral assessment is an important part of teratology testing and should be included in in-vivo screening procedures. Drugs used in this type of testing should have established metabolic pathways, effect specific neuronal systems, and produce quantifiable behavioral changes.
Psychological-factors; Detectors; Toxic-effects; Central-nervous-system; Laboratory-animals; Anesthetics; Pharmaceuticals;
Proceedings of a Workshop on Methodology for Assessing Reproductive Hazards in the Workplace, April 19-22, 1978, P.F. Infante and M.S. Legator, Eds. Division of Surveillance, Hazard Evaluations and Field Studies, NIOSH, U.S. Department of Health and Human Services