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In Vivo Teratogenicity Tests.

Authors
Blake-DA
Source
NIOSH 1980 Oct:219-225
Link
NIOSHTIC No.
00105779
Abstract
In-vivo teratogenicity tests are described. Procedures used in animal testing are reviewed, including treatment periods, doses, and evaluation criteria. Complications arising due to toxic doses and pharmacokinetics of the test substance are evaluated. Extrapolation of the results of animal tests to man is discussed. The author concludes that in-vivo teratogenicity tests in animals have poor predictability for humans. Test improvement will require better design and interpretation, and selection of more appropriate animal species based on comparable metabolism to man.
Keywords
In-vivo-study; Genetics; Animals; Research; Toxic-effects; Pharmacology;
Publication Date
19801001
Fiscal Year
1981
NTIS Accession No.
NTIS Price
NIOSH Division
DSHEFS;
Source Name
Proceedings of a Workshop on Methodology for Assessing Reproductive Hazards in the Workplace, April 19-22, 1978, P.F. Infante and M.S. Legator, Eds. Division of Surveillance, Hazard Evaluations and Field Studies, NIOSH, U.S. Department of Health and Human Services
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