The Detection of Environment Mutagens in Drosophila.
NIOSH 1980 Oct:191-200
Mutagenicity testing using Drosophila is discussed. Testing procedures are described, including feeding, injection and inhalation exposure methods. Selection of an appropriate genetic end point is considered. Bioactivation of indirect mutagens by Drosophila is described. Tabulated data on the mutagenicity of 11 classes of compounds is presented. The author concludes that the recessive lethal tests in Drosophila offers a rapid, sensitive and reproducible screening procedure for chemical mutagens. The sensitivity of the test can be further enhanced by the use of repair deficient strains and modified enzymatic activity.
Bioassays; Insects; Nutrition; Controlled-environment; Genetics; Chemical-processing; Enzyme-activity;
Proceedings of a Workshop on Methodology for Assessing Reproductive Hazards in the Workplace, April 19-22, 1978, P.F. Infante and M.S. Legator, Eds. Division of Surveillance, Hazard Evaluations and Field Studies, NIOSH, U.S. Department of Health and Human Services