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Dissimilarities in the toxic response of early chick embryos to DDT administered in different vehicles.

Authors
Swartz-WJ
Source
Bull Environ Contam Toxicol 1980 Dec; 25(6):898-901
NIOSHTIC No.
00105707
Abstract
The toxic effects of dichlorodiphenyltrichloroethane (50293) (DDT) were studied in early chick embryos. Chicken eggs were injected with 5 or 10 milligrams (mg) DDT dissolved in dimethylsulfoxide (67685) (DMSO), sesame oil or olive oil. The eggs were incubated at 37 degrees C and at 60 percent relative humidity. Control eggs were placed in a separate incubator under the same environmental conditions. After 5 days of incubation, the embryos were examined. Doses of 5 and 10mg of DDT dissolved in DMSO resulted in mortality rates of about 10 percent for both groups. The same doses of DDT in sesame oil resulted in mortality rates of 25 or 20 percent, respectively. In olive oil, the same doses caused a much higher rate of mortality. The author suggests that the means of administration should be considered when evaluating the toxicity of DDT on the early development of the chick embryo.
Keywords
NIOSH-Publication; NIOSH-Grant; Pesticides-and-agricultural-chemicals; Reproductive-effects; Teratogens; Lethal-concentrations; Exposure-methods; Biochemistry
Contact
Anatomy Louisiana State University 1542 Tulane Avenue New Orleans, LA 70112
CODEN
BECTA6
CAS No.
50-29-3; 67-68-5
Publication Date
19801201
Document Type
Journal Article
Funding Amount
706204.00
Funding Type
Grant
Fiscal Year
1981
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00835
Issue of Publication
6
ISSN
0007-4861
Source Name
Bulletin of Environmental Contamination and Toxicology
State
LA
Performing Organization
Louisiana State University, School of Medicine, Department of Anatomy, New Orleans, Louisiana
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