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Sensory irritation by toluene diisocyanate in single and repeated exposures.

Authors
Sangha-GK; Alarie-Y
Source
Toxicol Appl Pharmacol 1979 Sep; 50(3):533-547
NIOSHTIC No.
00105211
Abstract
The toxicity of toluene-diisocyanate (26471625) (TDI) was evaluated. Changes in respiratory rate were measured in mice exposed for 10 to 240 minutes to 0.007 to 2.0 parts per million (ppm) TDI vapor. Cumulative effects were tested in rats exposed to 0.007 to 1.18ppm TDI vapors 3 hours daily for 5 days. The severity of response and speed of recovery were dependent on exposure concentrations and duration of exposure. Repeated exposures to TDI at or above the threshold limit value for industrial exposure to TDI be reduced from the present 0.02ppm to 0.006ppm as a time weighted average and that no exposure above 0.02ppm be permitted.
Keywords
NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Pulmonary-function-tests; Chemical-analysis; Exposure-methods; Laboratory-animals; Tolerance-threshold; Standards
Contact
Occupational Health University of Pittsburgh 130 DE Soto Street Pittsburgh, PA 15213
CODEN
TXAPA9
CAS No.
26471-62-5
Publication Date
19790930
Document Type
Journal Article
Funding Amount
332059
Funding Type
Grant
Fiscal Year
1979
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00367
Issue of Publication
3
ISSN
0041-008X
Priority Area
Pulmonary-system-disorders
Source Name
Toxicology and Applied Pharmacology
State
PA
Performing Organization
University of Pittsburgh, Pittsburgh, Pennsylvania
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