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Epidemiologic investigation of occupational carcinogenesis using a serially additive expected dose model.

Authors
Smith-AH; Waxweiler-RJ; Tyroler-HA
Source
Am J Epidemiol 1980 Dec; 112(6):787-797
NIOSHTIC No.
00104926
Abstract
A serially additive expected dose model that epidemiologically analyzed carcinogenic agents present in the work environment is discussed. This model is based on the cumulative dose concept and compares the observed exposure of each worker with the exposures of fellow workers close to the worker in year of birth, and in age of commencement of work for the company being studied. Expected and observed exposures are calculated for each worker and exposure levels and duration are taken into consideration. This method is applied to a study of angiosarcomas of the liver and vinyl chloride exposures in a polymerization facility. The authors conclude that this model generates important amounts of information associated with chemical exposures and cancer, including exposure level relationships, latency data, and the synergistic possibility of chemicals.
Keywords
Epidemiology; Cancer; Workplace-studies; Occupational-exposure; Age-factors; Humans; Dose-response; Plastics; Liver-cancer; Synergism; Author Keywords: angiosarcoma; cancer; epidemiologic methods; occupational diseases; vinyl chloride
CODEN
AJEPAS
Publication Date
19801201
Document Type
Journal Article
Fiscal Year
1981
NTIS Accession No.
NTIS Price
Issue of Publication
6
ISSN
0002-9262
NIOSH Division
DSHEFS
Source Name
American Journal of Epidemiology
State
NC; OH
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