Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Fibrogenic potential of slags used as substitutes for sand in abrasive blasting operations.

Authors
Mackay-GR; Stettler-LE; Kommineni-C; Donaldson-HM
Source
Am Ind Hyg Assoc J 1980 Nov; 41(11):836-842
NIOSHTIC No.
00104403
Abstract
The fibrogenic potentials of coal-slag (68476960) and copper slag (67711982) used as substitutes for silica (7631869) sand in abrasive blasting operations were assessed. Rats were administered 20 milligrams (mg) of coal or copper grit slag, airborne copper slag, or standard quartz, by intralobar instillation. All surviving animals were autopsied after 10 months. Pulmonary fibrosis was seen in the coal-slag treated animals but not in the copper slag treated group. Granulomas were seen in the lungs from all treatment groups. The authors note that chronic inhalation experiments using animal models are necessary to assess the biological response to silica sand substitutes until data becomes available on responses of workers exposed to slags.
Keywords
NIOSH-Author; Laboratory-animals; Heavy-metals; Minerals; Silicates; Fibrogenicity; Fibrosis; Fibrous-bodies; Pulmonary-system-disorders; Carcinogenesis
CODEN
AIHAAP
CAS No.
68476-96-0; 67711-98-2; 7631-86-9
Publication Date
19801101
Document Type
Journal Article
Fiscal Year
1981
NTIS Accession No.
NTIS Price
Issue of Publication
11
ISSN
0002-8894
Source Name
American Industrial Hygiene Association Journal
State
OH
TOP