Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

The impact of low level cadmium feed on blood chemicals in male, Sprague-Dawley rats.

Authors
Rice-DP; Murthy-L; Shirley-T; Menden-E; Petering-HG
Source
Trace Subst Environ Health 1973 Jan; 7:305-311
Link
NIOSHTIC No.
00102179
Abstract
The effect of low concentration dietary cadmium (7440439) on hemoglobin, hematocrit and serum amylase, zinc (7440666), copper (7440508), and ceruloplasmin was studied in male rats fed a semipurified diet. Drinking water was supplemented with 2.5, 5, or 10 parts per million (ppm) zinc, 0.25, 0.5 or 1ppm copper, and 0 or 17.2ppm cadmium. The cadmium groups received no cadmium for the first 41 days and thereafter received a cadmium supplementation. The duration of the experiment was 76 days. Tail blood samples were taken at intervals during the study and at sacrifice. Serum zinc varied with the amount of zinc in the drinking water. Ingestion of cadmium caused a depression of serum zinc in the animals fed 5 or 10ppm zinc, but not in those animals fed 2.5ppm zinc. Cadmium depressed serum copper concentrations, which varied with the concentration of copper in the diet. Serum ceruloplasmin concentrations were also depressed by cadmium. Serum amylase concentrations were not significantly affected by dietary zinc, copper, or cadmium. There were no changes in blood hematocrit or hemoglobin. Cadmium feeding had a similar effect on serum copper and ceruloplasmin concentrations in male and female rats.
Keywords
NIOSH-Publication; NIOSH-Grant; Dietary-effects; Metallic-poisons; Biochemistry; Hematology; Laboratory-animals; Analytical-methods; Dose-response; Metabolism; Biological-effects
Contact
Environmental Health Kettering Laboratory Eden & Bethesda Avenues Cincinnati, Ohio 45219
CODEN
PUMTAG
CAS No.
7440-43-9; 7440-66-6; 7440-50-8
Publication Date
19730101
Document Type
Journal Article
Funding Amount
311966.00
Funding Type
Grant
Fiscal Year
1973
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00337
ISSN
0361-5162
Source Name
Trace Substances in Environmental Health
State
OH
Performing Organization
University of Cincinnati, Cincinnati, Ohio
TOP