Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

On the specific molecular configuration of neurotoxic aliphatic hexacarbon compounds causing central-peripheral distal axonopathy.

Authors
Spencer-P; Bischoff-MC; Schaumburg-HH
Source
Toxicol Appl Pharmacol 1978 Apr; 44(1):17-28
NIOSHTIC No.
00100180
Abstract
The neurotoxic effects of some aliphatic carbon compounds were studied. Test chemicals included 2-hepatone (110430), 3,5- heptanedione, 2,5-hexanedione (110134), 2,5-hexanediol (2935446), 2,4-hexadione, 2,3-hexanedione, 1,6-hexanediol (629118), glutaraldehyde (111308), 1,4-butanediol (110634), and acetone (67641). Rats were given the test compounds in drinking water and body weight, clinical condition, and fluid intake were recorded biweekly for 4 to 29 weeks. At the end of treatment, animals were autopsied. Rats treated with 1,4-butanediol initially lost weight, but gained weight normally after 8 weeks of treatment. Treatment with 2,5-hexanedione or 2,5-hexanediol caused decreased weight gain throughout the experiment. None of the other test chemicals affected weight gains. Tissues from rats treated with 2,5- hexanedione and 2,5-hexanediol showed giant axonal swelling in the central and peripheral nervous systems. Secondary demyelination and fiber breakdown were also noted in the peripheral nervous system. Tissues from rats treated with all other chemicals were normal. The authors concluded that 2,5-hexanedione and 2,5-hexanediol produce distal peripheral neuropathy in rats.
Keywords
NIOSH-Publication; NIOSH-Grant; Neurotoxicity; Ketones; Alcohols; Laboratory-animals; Neurological-disorders; Physiological-effects; Nerve-degeneration
Contact
Pathology Albert Einstein Coll of Med 1300 Morris Park Avenue Bronx, N Y 10461
CODEN
TXAPA9
CAS No.
110-43-0; 110-13-4; 2935-44-6; 629-11-8; 111-30-8; 110-63-4; 67-64-1
Publication Date
19780401
Document Type
Journal Article
Funding Amount
807725
Funding Type
Grant
Fiscal Year
1978
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00535
Issue of Publication
1
ISSN
0041-008X
Source Name
Toxicology and Applied Pharmacology
State
NY
Performing Organization
Yeshiva University, New York, New York
TOP