An electrodiagonstic study of the neurotoxicity of methyl n-amyl ketone.
Johnson-BL; Setzer-JV; Lewis-TR; Hornung-RW
NIOSH 1977 Jan; :1-12
The neurotoxic effects of methyl-n-amyl-ketone (110430) (MAK) inhalation in rats and monkeys were investigated. Rats and monkeys were exposed to 0, 131 or 1025 parts per million (ppm) MAK for 6 hours per day, 5 days per week for 9 months. The animals were tested neurologically and were autopsied following exposure. No neurological impairment was revealed at either MAK exposure. Sciatic tibial motor nerve conduction velocity was normal. Body weights remained normal. No impairments in locomotion, grip or gait were observed. Gross and histological examinations were normal. The authors conclude that MAK, is not neurotoxic and suggest that the relative neurotoxicity of the ketones may not necessarily increase with increased chain length of a ketone's molecule.
Laboratory-animals; Ketones; Physiological-effects; Physical-capacity; Histology; Toxic-substances; Nervous-system; Chemical-properties; Comparative-toxicology
Division of Biomedical and Behavioral Science, NIOSH, U.S. Department of Health, Education, and Welfare, Cincinnati, Ohio, 12 pages, 10 references