Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

An electrodiagonstic study of the neurotoxicity of methyl n-amyl ketone.

Authors
Johnson-BL; Setzer-JV; Lewis-TR; Hornung-RW
Source
NIOSH 1977 Jan; :1-12
Link
NIOSHTIC No.
00100021
Abstract
The neurotoxic effects of methyl-n-amyl-ketone (110430) (MAK) inhalation in rats and monkeys were investigated. Rats and monkeys were exposed to 0, 131 or 1025 parts per million (ppm) MAK for 6 hours per day, 5 days per week for 9 months. The animals were tested neurologically and were autopsied following exposure. No neurological impairment was revealed at either MAK exposure. Sciatic tibial motor nerve conduction velocity was normal. Body weights remained normal. No impairments in locomotion, grip or gait were observed. Gross and histological examinations were normal. The authors conclude that MAK, is not neurotoxic and suggest that the relative neurotoxicity of the ketones may not necessarily increase with increased chain length of a ketone's molecule.
Keywords
Laboratory-animals; Ketones; Physiological-effects; Physical-capacity; Histology; Toxic-substances; Nervous-system; Chemical-properties; Comparative-toxicology
CAS No.
110-43-0
Publication Date
19770101
Fiscal Year
1977
NTIS Accession No.
NTIS Price
NIOSH Division
DBBS
Source Name
Division of Biomedical and Behavioral Science, NIOSH, U.S. Department of Health, Education, and Welfare, Cincinnati, Ohio, 12 pages, 10 references
State
ME; OH
TOP