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Sister chromatid exchange in regenerating liver and bone marrow cells of mice exposed to styrene.

Authors
Connor-MK; Alarie-Y; Dombroske-RL
Source
Toxicol Appl Pharmacol 1979 Sep; 50(2):365-367
NIOSHTIC No.
00098193
Abstract
The use of a liver preparation for the study of chemically induced sister chromatid exchange (SCE) in-vivo was investigated. Hepatectomized and nonhepatectomized mice were exposed to styrene (100425) by inhalation and the liver and bone marrow regenerating cells were prepared for SCE analysis. SCE frequency was increased 3 to 4 times in the regenerating liver and bone marrow cells. Increases were seen in both nonhepatectomized and hepatectomized mouse cells. The authors conclude that the in-vivo SCE technique is suitable for the study of cytotoxicity in regenerating liver cells.
Keywords
NIOSH-Publication; NIOSH-Grant; Grants-other; Chromosome-damage; Analytical-methods; Exposure-methods; Cellular-reactions; Biochemistry; Sample-preparation
Contact
Occupational Health University of Pittsburgh 130 DE Soto Street Pittsburgh, PA 15213
CODEN
TXAPA9
CAS No.
100-42-5
Publication Date
19790915
Document Type
Journal Article
Funding Amount
332059
Funding Type
Grant
Fiscal Year
1979
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00367
Issue of Publication
2
ISSN
0041-008X
Priority Area
Other Occupational Concerns; Grants-other
Source Name
Toxicology and Applied Pharmacology
State
PA
Performing Organization
University of Pittsburgh, Pittsburgh, Pennsylvania
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