Sister chromatid exchange in regenerating liver and bone marrow cells of mice exposed to styrene.
Connor-MK; Alarie-Y; Dombroske-RL
Toxicol Appl Pharmacol 1979 Sep; 50(2):365-367
The use of a liver preparation for the study of chemically induced sister chromatid exchange (SCE) in-vivo was investigated. Hepatectomized and nonhepatectomized mice were exposed to styrene (100425) by inhalation and the liver and bone marrow regenerating cells were prepared for SCE analysis. SCE frequency was increased 3 to 4 times in the regenerating liver and bone marrow cells. Increases were seen in both nonhepatectomized and hepatectomized mouse cells. The authors conclude that the in-vivo SCE technique is suitable for the study of cytotoxicity in regenerating liver cells.
NIOSH-Publication; NIOSH-Grant; Grants-other; Chromosome-damage; Analytical-methods; Exposure-methods; Cellular-reactions; Biochemistry; Sample-preparation
Occupational Health University of Pittsburgh 130 DE Soto Street Pittsburgh, PA 15213
Other Occupational Concerns; Grants-other
Toxicology and Applied Pharmacology
University of Pittsburgh, Pittsburgh, Pennsylvania