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Serum Immunoglobulin levels in coal workers' pneumoconiosis.

Authors
Hahon-N; Morgan-WK; Petersen-M
Source
Ann Occup Hyg 1980; 23(2):165-174
NIOSHTIC No.
00097654
Abstract
Serum immunoglobulin (Ig) levels were examined in 155 U.S. coal miners with pneumoconiosis. Seventy one males, (21 underground miners and 50 nonminers) with no evidence of pneumoconiosis served as a comparison group. The 155 miners were divided into 3 major divisions: those with Caplans Syndrome, those with progressive massive fibrosis, and those with simple pneumoconiosis. Radial immunodiffusion plates were used to quantitate serum concentrations of alpha-1-antitrypsin, complement component (C3) and IgA, IgM, IgG and IgD. Most differences noted in serum immunoglobulin levels and protein concentrations were between the 3 pneumoconiosis groups. Significantly higher serum immunoglobulin levels and protein concentrations were apparent in workers with pneumoconiosis when compared to those without the disease. Elevated levels of either serum immunoglobulins or proteins were not associated with bronchitic conditions among the workers. The authors conclude that inhalation of occupationally associated agents or dust may selectively stimulate components of the immunoglobulin systems.
Keywords
NIOSH-Author; Measurement-methods; Respiratory-system-disorders; Humans; Analytical-methods; Analytical-instruments; Sample-preparation; Chemical-reactions; Immune-system; Occupational-exposure
CODEN
AOHYA3
Publication Date
19800101
Document Type
Journal Article
Fiscal Year
1980
NTIS Accession No.
NTIS Price
Issue of Publication
2
ISSN
0003-4878
Priority Area
Respiratory-system-disorders
Source Name
Annals of Occupational Hygiene
State
WV
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