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Clinical epidemiology of occupational neurotoxic disease.

Authors
Landrigan-PJ; Kreiss-K; Xintaras-C; Feldman-RG; Heath-CW Jr.
Source
Neurobehav Toxicol 1980 Jan; 2(1):43-48
Link
NIOSHTIC No.
00097189
Abstract
The clinical and epidemiological features of three outbreaks of neurologic diseases among workers in the United States caused by environmental exposure to neurotoxic chemicals are reviewed. The chemicals are Kepone (143500), dimethylaminopropionitrile (1738256) (DMAPN) and methyl-butyl-ketone (591786) (MBK). The symptoms and frequency of occurrences of cases, the categories of workers, incidence of exposure, the source of exposure and manner of detection are described. The authors suggest that many small isolated outbreaks of neurologic disease of obscure origin may be due to occupational or environmental exposure to neurotoxic chemicals. They conclude that recognition of the etiology of chemically induced neurologic illness and isolation of new neurotoxic syndromes from the mass of neurologic illness of undetermined origin will require a high index of clinical suspicion, careful ascertainment of occupational history, and a sensitivity to epidemiologic factors.
Keywords
NIOSH-Publication; NIOSH-Grant; Pesticides-and-agricultural-chemicals; Epidemiology; Neurological-disorders; Toxic-substances; Chemical-exposure; Industrial-factory-workers; Work-environment; Neurotoxicity
Contact
Neurology University Hospital 75 East Newton Street Boston, Mass 02118
CODEN
NETOD7
CAS No.
143-50-0; 1738-25-6; 591-78-6
Publication Date
19800101
Document Type
Journal Article
Funding Amount
416014.00
Funding Type
Grant
Fiscal Year
1980
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00984
Issue of Publication
1
ISSN
0191-3581
Source Name
Neurobehavioral Toxicology
State
MA
Performing Organization
University Hospital (Boston), Boston, Massachusetts
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