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Animal models of hypersensitivity pneumonitis: a review.

Authors
Olenchock-SA
Source
Ann Allergy 1977 Feb; 38(2):119-126
Link
NIOSHTIC No.
00095026
Abstract
Animal model studies of the etiology of hypersensitivity pneumonitis are reviewed. The studies used guinea pigs, rabbits, cattle, rats, dogs, and monkeys. Animal models reviewed demonstrate differences in results based on the use of a soluble antigen or a particulate one that may more closely mimic the natural situation; antigens that have not been ascribed to the growing list of agents causing hypersensitivity pneumonitis; or unnatural methods of immunization. The author concludes that further elucidation of the interactions of inhaled antigens and the complement system is needed. He recommends additional efforts to determine the direct actions of fungal toxins on the respiratory tract, the irritant effects of particulate dusts, and the contributory effects of the microbial flora.
Keywords
NIOSH-Author; Occupational-health; Serological-analysis; Clinical-studies; Respiratory-system-disorders; Farmer's-lung; Extrinsic-allergic-alveolitis; Antigen-antibody-reactions; Immunology; Respiratory-irritants
CODEN
ANAEA3
Publication Date
19770201
Document Type
Journal Article
Fiscal Year
1977
NTIS Accession No.
NTIS Price
Issue of Publication
2
ISSN
0003-4738
NIOSH Division
DRDS
Priority Area
Respiratory-system-disorders
Source Name
Annals of Allergy
State
WV
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