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Mitogenic response to Micropolyspora faeni cell walls.

Authors
Smith-SM; Snyder-IS; Buyrrell-R
Source
J Allergy Clin Immunol 1980 Apr; 65(4):298-304
NIOSHTIC No.
00094467
Abstract
The mitogenic response of splenic lymphocytes from unsensitized guinea pigs to cell wall fractions prepared from Micropolyspora faeni (M-faeni) was investigated. Three M-faeni cell wall fractions were incubated with lymphocyte preparations for 48 hours. All of the fractions were mitogenic for the lymphocytes, and the response was dose dependent. The most active cell wall fractions were primarily B cell mitogens. The heat stable mitogenic reactivity was associated with polypeptide and polysaccharide. The mitogenic potential of the reactive material decreased after lysozyme digestion, indicating that part of the material was peptidoglycan. The authors suggest that mitogenic reactivity is host related.
Keywords
NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Respiratory-system-disorders; Organic-dusts; Extrinsic-allergic-alveolitis; Farmers-lung; Cell-division; Nuclear-chemistry; Cellular-reactions; Dose-response; Biological-responses
Contact
Microbiology West Virginia University Med C Department of Microbiology Morgantown, W VA 26506
CODEN
JACIBY
Publication Date
19800401
Document Type
Journal Article
Funding Amount
289015.00
Funding Type
Grant
Fiscal Year
1980
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00360
Issue of Publication
4
ISSN
0091-6749
Priority Area
Pulmonary-system-disorders; Respiratory-system-disorders
Source Name
Journal of Allergy and Clinical Immunology
State
WV
Performing Organization
West Virginia University, Morgantown, West Virginia
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