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Special occupational hazard review for benzidine-based dyes.

Authors
Gregory-AR; Bamel-IP; Mackison-F
Source
NIOSH 1980 Jan; :1-66
NIOSHTIC No.
00094105
Abstract
Information concerning the carcinogenicity and metabolism of benzidine (92875) based dyes is reviewed. Research has indicated that some of the dyes have induced tumors in animals; occupational exposure to benzidine based dye is related to an increased incidence of bladder cancer in workers; the dyes are metabolized in animals to the carcinogen benzidine; and the enzyme azoreductase, which breaks down these dyes to benzidine, is present in animals and humans. The carcinogenic impurities of 4-aminobiphenyl (92671) and 2,4- diaminoazobenzene (495545) were found in one benzidine based dye and may contribute to the dye's carcinogenic potential. The authors conclude that all benzidine based dyes should be recognized as potential human carcinogens. NIOSH recommends that the production, use, storage, packaging, and distribution of all benzidine based dyes be discontinued in light of present evidence of potential carcinogenic risks.
Keywords
NIOSH-Author; NIOSH-Criteria-Document; Carcinogens; Metabolic-effects; Dyestuffs; Tumorigens; Enzymatic-activity; Materials-handling; Risk-factors; Aromatic-hydrocarbons
CAS No.
92-87-5; 92-67-1; 495-54-5
Publication Date
19800101
Document Type
Numbered Publication; Criteria Document
Fiscal Year
1980
NTIS Accession No.
PB81-225633
NTIS Price
A05
Identifying No.
(NIOSH) 80-109
NIOSH Division
DCDSD
Source Name
National Institute for Occupational Safety and Health
State
OH
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