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Induction of 6-thioguanine resistance in Chinese hamster lung cells treated with dimethylnitrosamine' 2-amino-anthracene or 7,12-dimethylbenz(A)anthracene in the presence of rat liver microsomes.

Authors
Huang-SL; Whong-WZ
Source
Toxicol Lett 1979 Apr; 3(4):209-214
NIOSHTIC No.
00093839
Abstract
The mutagenic effects of dimethylnitrosamine (62759) (DMN), 2- aminoanthracene (613138) (2-AA), and 7,12-dimethylbenz(a)anthracene (57976) (7,12-DMBA) on cultured Chinese hamster lung cells were investigated at the hypoxanthine guanine phosphoribosyl transferase (HGPRT) locus. All three compounds induce 6-thioguanine (6TG) resistance only in the presence of rat liver microsomes. The mutation frequencies induced by the compounds are dose dependent. The authors conclude that DMN, 2-AA, and 7,12-DMBA require metabolic activation for mutagenicity. They suggest that the mutagenic potential of carcinogens and other chemical agents can be detected and quantitated through the use of Chinese hamster cells and microsome activation.
Keywords
NIOSH-Author; Mutagenesis; Chemical-exposure; Laboratory-animals; Oxidative-metabolism; Subcellular-structure; Cellular-reactions; Enzymatic-activity; Analytical-methods; Diagnostic-techniques
CODEN
TOLED5
CAS No.
62-75-9; 613-13-8; 57-97-6
Publication Date
19790401
Document Type
Journal Article
Fiscal Year
1979
NTIS Accession No.
NTIS Price
Issue of Publication
4
ISSN
0378-4274
Source Name
Toxicology Letters
State
NC
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