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Metabolic Reduction of Benzidine Azo Dyes to Benzidine and its Metabolites and Their Possible Relationship to Carcinoma of the Bladder in Man.

Authors
Boeniger-M
Source
NIOSH 1979:168 pages
Link
NIOSHTIC No.
00093824
Abstract
Information about the carcinogenicity of benzidine (92875) in man and in experimental animals is reviewed, along with results of studies on the metabolism of benzidine and azo compounds, and epidemiological surveys of industries that use azo dyes. The author concludes that workers exposed to benzidine based dyes may metabolically convert the dyes to carcinogenic amine. The number of workers with potential exposure to benzidine is greater than previously thought. Benzidine based dyes should be handled as carcinogens, and substitute dyes should be used whenever possible.
Keywords
NIOSH-Author; Carcinogenesis; Chemical-exposure; Humans; Laboratory-animals; Metabolic-effects; Epidemiology; Dyes; Work-environment; Sampling-methods; Risk-factors; Control-measures;
CAS No.
92-87-5;
Publication Date
19790101
Fiscal Year
1979
NTIS Accession No.
NTIS Price
NIOSH Division
DSHEFS;
Source Name
Industrial Hygiene Section, Industry-Wide Studies Branch, NIOSH, Cincinnati, Ohio, 168 pages, 189 references
State
OH;
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