Metabolic Reduction of Benzidine Azo Dyes to Benzidine and its Metabolites and Their Possible Relationship to Carcinoma of the Bladder in Man.
NIOSH 1979:168 pages
Information about the carcinogenicity of benzidine (92875) in man and in experimental animals is reviewed, along with results of studies on the metabolism of benzidine and azo compounds, and epidemiological surveys of industries that use azo dyes. The author concludes that workers exposed to benzidine based dyes may metabolically convert the dyes to carcinogenic amine. The number of workers with potential exposure to benzidine is greater than previously thought. Benzidine based dyes should be handled as carcinogens, and substitute dyes should be used whenever possible.
NIOSH-Author; Carcinogenesis; Chemical-exposure; Humans; Laboratory-animals; Metabolic-effects; Epidemiology; Dyes; Work-environment; Sampling-methods; Risk-factors; Control-measures;
Industrial Hygiene Section, Industry-Wide Studies Branch, NIOSH, Cincinnati, Ohio, 168 pages, 189 references