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n-Hexane-"free" hexane mixture fails to produce nervous system damage.

Authors
Egan-G; Spencer-P; Schaumburg-H; Murray-KJ; Bischoff-M; Scala-R
Source
Neurotoxicology 1980 Feb; 1(3):515-524
NIOSHTIC No.
00093699
Abstract
The effects of chronic inhalation of a hexane (110543) mixture of 6 carbon (C-6) isomers free of n-hexane were examined. Male rats were exposed for 22 hours per day, 7 days per week for up to 6 months to 500 parts per million of the vapor. A positive control group was exposed to 100ppm of methyl-n-butyl-ketone (591786) (MnBK) and a negative control group was exposed to 500ppm of methyl-ethyl-ketone (78933) (MEK). Two animals from each test group were sacrificed after 2, 4, or 6 months of exposure for neuropathological examination. The animals exposed to the C-6 isomer mixture had no signs of neurotoxicity. The rats in the positive control group developed peripheral neuropathy after 4 months. Rats in the negative control group did not develop any signs of polyneuropathy. The authors conclude that hexane isomers that are free of n-hexane are not neurotoxic.
Keywords
NIOSH-Publication; NIOSH-Grant; Neurotoxic-effects; Industrial-organic-chemicals; Neurotoxins; Neurological-reactions; Physiological-response; Neuropathology; Exposure-limits; Chemical-factory-workers; Laboratory-animals
Contact
Pathology Albert Einstein Coll of Med 1300 Morris Park Avenue Bronx, N Y 10461
CODEN
NRTXDN
CAS No.
110-54-3; 591-78-6; 78-93-3
Publication Date
19800201
Document Type
Journal Article
Funding Amount
807725
Funding Type
Grant
Fiscal Year
1980
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00535
Issue of Publication
3
ISSN
0161-813X
Priority Area
Neurotoxic Disorders; Neurotoxic-effects
Source Name
Neurotoxicology
State
NY
Performing Organization
Yeshiva University, New York, New York
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