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Carcinogenicity of beryllium: Review of the literature.

Authors
Groth-DH
Source
Environ Res 1980 Feb; 21(1):56-62
NIOSHTIC No.
00093495
Abstract
Experimental findings that demonstrate the carcinogenic aspects of beryllium (7440417) are reviewed. Beryllium compounds were the first nonradioactive chemicals that were found to cause osteogenic sarcomas and the first to produce lung cancer by inhalation in animals. Eleven different authors have published articles demonstrating that osteogenic sarcomas can be produced in rabbits by intravenous injection of beryllium compounds. Six other authors have published articles concluding that pulmonary neoplasms may be induced in rats by inhalation exposures to and intratracheal injections of beryllium compounds. Lung cancer has been produced in monkeys after inhalation exposure to beryllium. In view of these findings, the author concludes that beryllium is a carcinogen in laboratory animals, and that all beryllium compounds should be considered potential carcinogens.
Keywords
NIOSH-Author; Metallic-poisons; Carcinogenesis; Respiratory-system-disorders; Laboratory-animals; Air-contamination; Exposure-methods; Tumorigenesis
CODEN
ENVRAL
CAS No.
7440-41-7
Publication Date
19800201
Document Type
Journal Article
Fiscal Year
1980
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
0013-9351
NIOSH Division
DBBS
Priority Area
Respiratory-system-disorders
Source Name
Environmental Research
State
OH
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