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Nonneoplastic effects of vinyl chloride in mouse lung.

Authors
Suzuki-Y
Source
Environ Res 1980 Feb; 21(1):235-253
NIOSHTIC No.
00093490
Abstract
Nonneoplastic effects in mouse lung were investigated by light and electron microscopy. Mouse lung tissue containing tumors caused by exposure to vinyl-chloride monomer (75014) was prepared for microscopy. Light microscopy showed proliferation and hypertrophy of the terminal bronchiolar cells and hypersecretion of the epithelial mucin in the goblet cells. Hyperplasia of alveolar epithelium and mobilization of alveolar macrophages were also observed. In electron microscope studies, Clara cells showed proliferation of the rough and smooth surfaced endoplasmic reticulum. Large and abnormally shaped mitochondria were seen and similar alterations were found in the ciliated cells. Submicroscopic changes in the pulmonary alveoli were also observed. The author suggests that the alveolar capillary endothelium and the septal cell probably are also affected by vinyl-chloride.
Keywords
NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Laboratory-animals; Cellular-reactions; Lung-cancer; Dose-response; Plastic-materials-and-resins; Chemical-factory-workers; Histopathology
Contact
Community Medicine Mount Sinai School of Med Fifth Avenue & 100Th Street New York, N Y 10029
CODEN
ENVRAL
CAS No.
75-01-4
Publication Date
19800201
Document Type
Journal Article
Funding Amount
286553.00
Funding Type
Grant
Fiscal Year
1980
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00681
Issue of Publication
1
ISSN
0013-9351
Priority Area
Pulmonary-system-disorders
Source Name
Environmental Research
State
NY
Performing Organization
Mount Sinai School of Medicine, New York, New York
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