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Beryllium: an etiologic agent in the induction of lung cancer, nonneoplastic respiratory disease, and heart disease among industrially exposed workers.

Authors
Wagnoner-JK; Infante-PF; Bayliss-DL
Source
Environ Res 1980 Feb; 21(1):15-34
NIOSHTIC No.
00093482
Abstract
The cause specific mortality of employees exposed to beryllium (7440417) at a production facility in Pennsylvania was investigated. The population included 3,055 White males who were employed sometime between January 1, 1942 and September, 1968. During this time, a total of 875 deaths occurred among the study cohort, compared to 816.86 expected deaths in the general male population. Significant excess mortality rates among the workers occurred for respiratory system and heart diseases. There was an excess lung cancer mortality rate, but this could not be related to age, chance, self selection, study group selection, exposure to other agents, or place of residence. Cigarette smoking habits alone did not explain the lung cancer excess. The effect of other occupational exposures could not be assessed because lifetime employment histories of cohort members were unavailable. The authors note that it was unlikely that undefined occupational exposures could account for the excess of lung cancer mortality and conclude that beryllium is probably carcinogenic to man.
Keywords
NIOSH-Author; Industrial-factory-workers; Metallic-poisons; Work-environment; Mortality-data; Physiological-effects; Statistical-analysis; Carcinogenesis; Respiratory-system-disorders; Cardiac-disorders; Risk-factors
CODEN
ENVRAL
CAS No.
7440-41-7
Publication Date
19800201
Document Type
Journal Article
Fiscal Year
1980
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
0013-9351
NIOSH Division
DSHEFS
Priority Area
Respiratory-system-disorders
Source Name
Environmental Research
State
PA; OH; DC
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