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Studies on the biochemical basis of distal axonopathies II. Specific inhibition of fructose-6-phosphate kinase by 2,5-hexanedione and methyl-butyl ketone.

Authors
Sabri-MI; Ederle-K; Holdsworth-CE; Spencer-PS
Source
Neurotoxicology 1979 Jan; 1(2):285-297
NIOSHTIC No.
00093280
Abstract
The effects of 2,5-hexanedione (110134) (2,5-HD) and methyl-n-butyl- ketone (591786) (MnBK) on phosphofructokinase (PFK) activity were examined. Activities of PFK in brain homogenates were also determined in animals chronically intoxicated with 5 percent 2,5-HD in their drinking water for 10 to 12 weeks. Lactic dehydrogenase (LDH) activity was studied for comparison. The neurotoxic hexacarbon compounds 2,5-HD and MnBK inhibited PFK activity in pure crystalline form and in brain homogenates. 2,5-HD was considerably more inhibitory than MnBK. LDH activity was unaffected both in- vitro and in-vivo. PFK activity was also reduced in brain homogenates obtained from the chronically intoxicated rats. The authors conclude that neurotoxic hexacarbon compounds inhibit the activity of enzymes required for energy production and maintenance of nerve fiber integrity.
Keywords
NIOSH-Publication; NIOSH-Grant; Neurotoxic-effects; Industrial-organic-chemicals; In-vitro-study; Neurotoxins; Enzyme-activity; Enzymatic-inhibition; Biochemical-effects; Biochemical-reactions
Contact
Pathology Albert Einstein Coll of Med 1300 Morris Park Avenue Bronx, N Y 10461
CODEN
NRTXDN
CAS No.
110-13-4; 591-78-6
Publication Date
19790101
Document Type
Journal Article
Funding Amount
807725
Funding Type
Grant
Fiscal Year
1979
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00535
Issue of Publication
2
ISSN
0161-813X
Priority Area
Neurotoxic Disorders; Neurotoxic-effects
Source Name
Neurotoxicology
State
NY
Performing Organization
Yeshiva University, New York, New York
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