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Neurological dysfunction of the bladder in workers exposed to dimethylaminopropionitrile.

Authors
Kreiss-K; Wegman-DH; Niles-CA; Siroky-MB; Krane-RJ; Feldman-RG
Source
JAMA J Am Med Assoc 1980 Feb; 243(8):741-745
NIOSHTIC No.
00092988
Abstract
An outbreak of bladder dysfunction among workers at a polyurethane (68400679) foam manufacturing factory in Massachusetts was investigated. Interviews were conducted with 208 employees about their job descriptions, use of protective clothing, and medical symptoms. Neurologic evaluations were performed on eight symptomatic workers. Symptoms were identified among 104 workers, most of whom worked at the production line. The workers reported hesitancy, the need to strain at urination, decreased urinary stream, and increased duration of urination. Some reported pain or discomfort. Symptoms or incidence were not sex related. Sexual difficulties also were reported. Sensory and sensorimotor neuropathy were found in seven of the eight affected workers that were tested. The onset of this epidemic was associated with the introduction of dimethylaminopropionitrile (1738256) (DMAPN) into the production process. When DMAPN was removed from the process, symptoms ceased abruptly, and no new outbreaks were reported. The authors conclude that DMAPN produces bladder dysfunction without producing frequent complaints of other organ or nerve dysfunction. They suggest that the mechanism of DMAPN action needs to be studied in animals.
Keywords
NIOSH-Publication; NIOSH-Contract; Contract-210-78-0015; Plastic-materials; Chemical-factory-workers; Chemical-exposure; Sensory-perceptual-disorders; Neurological-disorders; Urogenital-system-disorders; Toxic-substances; Epidemiology; Recovery-time; Neurotoxicity
CODEN
JAMAAP
CAS No.
68400-67-9; 1738-25-6
Publication Date
19800229
Document Type
Journal Article
Funding Type
Contract
Fiscal Year
1980
NTIS Accession No.
NTIS Price
Identifying No.
Contract-210-78-0015
Issue of Publication
8
ISSN
0098-7484
Source Name
Journal of the American Medical Association
State
MA
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