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Radon daughter exposure and respiratory cancer quantitative and temporal aspects.

Authors
Lundin-FE Jr.; Wagoner-JK; Archer-VE
Source
NIOSH 1971 Jun; :1-193
Link
NIOSHTIC No.
00092887
Abstract
Epidemiologic and pathologic data on radon (10043922) daughter exposure and respiratory cancer among uranium (7440611) miners were evaluated. A statistically significant excess of respiratory cancer was identified among white uranium miners at each cumulative radiation exposure category down to and including the range of 120 to 359 working level months (WLM). Increased mortality from respiratory cancer and a dose relationship was indicated among uranium miners with or without other hard rock mining experience. Statistical analysis of respiratory cancer among workers in the potash (584087) industry and Indians in the southwest United States indicated that factors other than radiation were not responsible for the excess malignancies. A significant excess of small cell undifferentiated type tumors among uranium miners with respiratory cancer indicated a causal role of airborne radiation. This cell type was shown to increase with increasing cumulative radiation exposure. Animal studies indicated that the lung is relatively radiosensitive from the standpoint of carcinogenesis and that lung cancer may occur after exposure to 100 rads (ionizing absorbed dose of radiation). The risk of respiratory cancer per unit of exposure appeared to be greater in lower cumulative radiation groups than in higher ones. The authors conclude that a reduction in the federal standard for radon daughter exposure from 12 to 4 WLM per year may not yield the same proportionate reduction in respiratory cancer that would be expected from a linear relationship.
Keywords
NIOSH-Publication; NIOSH-Author; Radiation-exposure; Lung-cancer; Uranium-miners; Morbidity-rates; Epidemiology; Risk-factors; Mortality-rates; Exposure-limits; Pulmonary-system-disorders; Cigarette-smoking
CAS No.
10043-92-2; 7440-61-1; 584-08-7
Publication Date
19710601
Fiscal Year
1971
NTIS Accession No.
PB-204871
NTIS Price
A10
Priority Area
Pulmonary-system-disorders
Source Name
NIOSH-NIEHS Joint Monograph No. 1, NIOSH, Cincinnati, Ohio
State
OH
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