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Acrylonitrile pharmacodynamics and mutagenesis.

Authors
Wolff-MS
Source
Environmental Science Laboratory, Mount Sinai School of Medicine of the City University of New York, New York, New York 1977 Jul; :1-8
Link
NIOSHTIC No.
00092785
Abstract
The elimination routes and metabolism of acrylonitrile (107131) (AN) were investigated in the rat by studying kinetics in the blood following administration of 5 to 60 milligrams per kilogram doses. Blood samples were obtained at 5 to 10 minute intervals, and AN concentrations were measured using gas chromatography. AN concentrations in urine, feces, fat, and liver also were obtained where possible. Efforts to characterize possible metabolites were unsuccessful. AN had biphasic kinetic elimination from blood with half lives of approximately 10 to 50 minutes for the fast and slow rate constants, respectively. Both rates were dose dependent, and both were observed in liver tissue in-vitro. Induction with phenobarbital did not change the pharmacokinetic curve. Total AN measured in feces, urine, and tissues, represented only 3 to 30 percent of the administered dose, even at very short intervals following administration. AN did not appear to accumulate in the body, due to rapid, unchanged excretion in urine and feces and to rapid metabolism. The author concludes that the pharmacodynamics of AN are complex with at least two major metabolic pathways.
Keywords
NIOSH-Grant; Neurotoxic-effects; Laboratory-animals; Malignant-neoplasms; Mutagenesis; Body-retention; Dose-response; Hematology; Chromatographic-analysis; Metabolism
Contact
Community Medicine Mount Sinai School of Medicine Fifth Avenue and 100Th Street New York, N Y 10029
CAS No.
107-13-1
Publication Date
19770701
Document Type
Final Grant Report
Funding Amount
100464
Funding Type
Grant
Fiscal Year
1977
NTIS Accession No.
PB88-246947
NTIS Price
A02
Identifying No.
Grant-Number-R01-OH-00702
NIOSH Division
OEP
Priority Area
Neurotoxic Disorders; Neurotoxic-effects
Source Name
Environmental Science Laboratory, Mount Sinai School of Medicine of the City University of New York, New York, New York
State
NY
Performing Organization
Mount Sinai School of Medicine, New York, New York
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