Environmental hydrocarbons produce degeneration in cat hypothalamus and optic tract.
Science 1978 Jan; 199(435):199-200
The effects of 2,5-hexanedione (110134), a neurotoxic metabolite of n-hexane (110543) and methyl-n-butyl-ketone (591786) on distal axonal degeneration were studied in cats. Prolonged, low level administration to the animals produced an unsteady gait and distal weakness in the lower extremities after 60 to 75 days. The characteristic morphological changes were abnormally large fibers with swollen axons displaying abnormal accumulations of 10 millimeter (mm) neurofilaments, and myelin sheaths inappropriately thin for their axon diameter. Axonal swellings were present in the rostral gracile, dorsal spinocerebelar, and caudal corticospinal tracts in the early stages of intoxication, and advanced changes consisted of distal fiber disintegration. The authors conclude that prolonged, low level industrial or environmental exposure to n- hexane will provoke subtle changes in areas of the nervous system which may be vital to memory and vision.
NIOSH-Publication; NIOSH-Grant; Low-level-exposure; Long-term-exposure; Neurotoxins; Nerve-degeneration; Nervous-tissue; Histological-changes; Histomorphology; Physiological-effects; Pathologic-effects
Pathology Albert Einstein Coll of Med 1300 Morris Park Avenue Bronx, N Y 10461
110-13-4; 110-54-3; 591-78-6
Yeshiva University, New York, New York