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Environmental hydrocarbons produce degeneration in cat hypothalamus and optic tract.

Authors
Schaumburg-HH; Spencer-PS
Source
Science 1978 Jan; 199(435):199-200
NIOSHTIC No.
00092694
Abstract
The effects of 2,5-hexanedione (110134), a neurotoxic metabolite of n-hexane (110543) and methyl-n-butyl-ketone (591786) on distal axonal degeneration were studied in cats. Prolonged, low level administration to the animals produced an unsteady gait and distal weakness in the lower extremities after 60 to 75 days. The characteristic morphological changes were abnormally large fibers with swollen axons displaying abnormal accumulations of 10 millimeter (mm) neurofilaments, and myelin sheaths inappropriately thin for their axon diameter. Axonal swellings were present in the rostral gracile, dorsal spinocerebelar, and caudal corticospinal tracts in the early stages of intoxication, and advanced changes consisted of distal fiber disintegration. The authors conclude that prolonged, low level industrial or environmental exposure to n- hexane will provoke subtle changes in areas of the nervous system which may be vital to memory and vision.
Keywords
NIOSH-Publication; NIOSH-Grant; Low-level-exposure; Long-term-exposure; Neurotoxins; Nerve-degeneration; Nervous-tissue; Histological-changes; Histomorphology; Physiological-effects; Pathologic-effects
Contact
Pathology Albert Einstein Coll of Med 1300 Morris Park Avenue Bronx, N Y 10461
CODEN
SCIEAS
CAS No.
110-13-4; 110-54-3; 591-78-6
Publication Date
19780113
Document Type
Journal Article
Funding Amount
807725.00
Funding Type
Grant
Fiscal Year
1978
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00535
ISSN
0036-8075
Source Name
Science
State
NY
Performing Organization
Yeshiva University, New York, New York
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