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Chemical characterization of uncoated asbestos fibers from the lungs of asbestos workers by electron microprobe analysis.

Authors
Langer-A; Rubin-I; Selikoff-I; Pooley-F
Source
J Histochem Cytochem 1972; 20(9):735-740
NIOSHTIC No.
00092404
Abstract
Lung tissue specimens from anthophyllite (17068789), amosite (12172735), and crocidolite (12001284) asbestos workers were analyzed to determine whether uncoated amphibole asbestos fibers remain chemically intact in the human body. Tissues were prepared by carbon extraction and were examined first with an electron microprobe and later with a transmission electron microscope. Area diffraction patterns were obtained on some fibers to verify their identity as amphiboles. Uncoated fibers were characterized chemically and compared with standard reference asbestos samples. Standard ratio comparison indicated that the lung fibers from anthophyllite and amosite workers were depleted in magnesium, and that asbestos fibers from all lung tissues showed an increase in iron content. The authors conclude that the characteristic chemistry of uncoated asbestos fibers in the lungs of asbestos workers were comparable to standard reference fibers; however detectable, statistically significant chemical changes were observed.
Keywords
NIOSH-Publication; NIOSH-Grant; Asbestos-mining; Asbestos-workers; Miners; Tissue-reactions; Histological-changes; Asbestos-dusts; Fibrous-dusts; Chemical-reactions; Chemical-analysis
Contact
Community Medicine MT Sinai School of Medicine Fifth Avenue and 100 Street New York, N Y 10029
CODEN
JHCYAS
CAS No.
17068-78-9; 12172-73-5; 12001-28-4
Publication Date
19720101
Document Type
Journal Article
Funding Amount
207338.00
Funding Type
Grant
Fiscal Year
1972
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00305
Issue of Publication
9
ISSN
0022-1554
Source Name
Journal of Histochemistry and Cytochemistry
State
NY
Performing Organization
Mount Sinai School of Medicine, New York, New York
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