Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

A comparative study of the effects of carbon monoxide and methylene chloride on human performance.

Authors
Putz-VR; Johnson-BL; Setzer-JV
Source
J Environ Pathol Toxicol 1979 May/Jun; 2(5):97-112
NIOSHTIC No.
00091979
Abstract
Behavioral effects due to carbon monoxide (630080) (CO) or methylene chloride (75092) (MeC) inhalation were investigated. Six male and six nonpregnant female humans were exposed to CO or MeC concentrations designed to produce maximum 5 percent carboxyhemoglobin (COHb) concentrations during the fourth hour of exposure, and were assigned an eye and hand coordination task that was performed concurrently with peripheral brightness monitoring, and an auditory vigilance task. Subjects also were studied under no exposure as a control condition. Interactions between task difficulty levels, exposure time, and exposure conditions for response vectors were analyzed by multivariate analysis of variance. Finger prick blood samples were taken before and after exposure, and alveolar breath samples were collected every hour, during and after exposure. Both MeC and CO in the experimental concentrations had adverse behavioral effects which were similar in direction but varied in magnitude with certain tasks. The deteriorating effects of MeC and CO generally were evident only under difficult or demanding task conditions. The authors recommend that the effects of MeC and CO in concentrations sufficient to produce 5 percent COHb, either in combination or singly, be evaluated carefully for the arousal impact on workers.
Keywords
NIOSH-Author; Toxins; Blood-chemicals; Anesthetics; Organic-solvents; Blood-sampling; Physiological-stress; Psychological-effects; Performance-capability; Productivity; Performance-capacity; Task-performance; Humans; Research-laboratories; Furniture-stripping; Paint-stripping; Paint-removers; Furniture-repair
CODEN
JEPTDQ
CAS No.
630-08-0; 75-09-2
Publication Date
19790501
Document Type
Journal Article
Editors
Bridbord-K; French-J
Fiscal Year
1979
NTIS Accession No.
NTIS Price
Issue of Publication
5
ISSN
0146-4779
NIOSH Division
DBBS
Source Name
Journal of Environmental Pathology and Toxicology. Toxicological and Carcinogenic Health Hazards in the Workplace: proceedings of the First Annual NIOSH Scientific Symposium, Cincinnati, Ohio, April 1978
State
MD; OH
TOP