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Relation of smoking to neoplasia in asbestos workers (final report).

Authors
Selikoff-IJ
Source
Environmental Sciences Laboratory, Mount Sinai School of Medicine, New York, New York 1979 May; :1-25
Link
NIOSHTIC No.
00091886
Abstract
A cohort of 17,800 male asbestos (1332214) insulation workers was compared with a control group of 73,763 males to evaluate the combined effects of cigarette smoking and exposure to asbestos dust in relation to death from lung cancer and chronic infectious pulmonary diseases. The relationship to cancer other than mesothelioma and lung cancer and the degree to which occupational exposure to asbestos dust increases total death rates from all cancers combined also was studied. Data were collected for the period between January 1, 1967 and December 31, 1976. A strong synergistic effect between asbestos dust and cigarette smoke exposure and the risk of lung cancer was indicated. Among asbestos workers, former cigarette smokers had substantially lower death rates than smokers who maintained the habit. Cigarette smoking also increased the risk of death from asbestosis. Exposure to asbestos dust resulted in increased death rates from lung cancer, mesothelioma, and asbestosis. Exposure to the dust also increased death rates from cancers of the colon and rectum, esophagus, kidney, and the group comprising the larynx, pharynx, and buccal cavity.
Keywords
NIOSH-Grant; Pulmonary-system-disorders; Asbestos-fibers; Airborne-dusts; Carcinogenesis; Respiratory-system-disorders; Mortality-data; Smoking; Physiological-effects; Asbestos-products; Insulation-workers
Contact
Community Medicine Mount Sinai School of Medicine Fifth Avenue and 100 Street New York, N Y 10029
CAS No.
1332-21-4
Publication Date
19790530
Document Type
Final Grant Report
Funding Amount
629948
Funding Type
Grant
Fiscal Year
1979
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00320
NIOSH Division
OEP
Source Name
Environmental Sciences Laboratory, Mount Sinai School of Medicine, New York, New York
State
NY
Performing Organization
Mount Sinai School of Medicine, New York, New York
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