Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Axonal specification of Schwann cell expression and myelination.

Authors
Spencer-PS
Source
Physiology and Pathobiology of Axons. Waxman-SG, ed., New York: Raven Press, 1978 Jan; :389-405
Link
NIOSHTIC No.
00091811
Abstract
A unitary theory of neuronal regulation of Schwann cell function which attempts to correlate contemporary theories of cell sorting, interaction, and metabolic regulation is proposed by the authors. The theory is based on the assumptions that Schwann cells form a single undifferentiated population in the fetal nerve; that complementary molecular sites exist on the axolemma and enable the Schwann cell to adhere to the axon, provide contact inhibition, and produce myelin; and that during fetal development the axolemma of axons to be myelinated progresses from an undifferentiated to a differentiated state. Several phases of the myelination process are discussed and related to initial and terminal regions of myelinated fibers, and to the central and peripheral nervous system transitional region. Instances of nonaxonal myelination are mentioned. The proposed theory is used to explain reactive and pathological states based on axon and Schwann cell relationships. Methods used to prepare Schwann cells for investigation are included. The authors conclude that peripheral nerves provide the ideal site to study neuronal regulation because of their simple organization and accessibility, and that the elucidation of cellular relationships in this area may prove relevant to those present in the brain.
Keywords
NIOSH-Grant; Neurotoxic-effects; Membrane-dysfunction; Nerve-fibers; Metabolism; Biochemical-reactions; Nuclear-membrane; Physiological-function; Peripheral-nervous-system; Synergism; Cellular-function; Cytological-analysis; Research-laboratories
Contact
Pathology Albert Einstein Coll of Med 1300 Morris Park Avenue Bronx, N Y 10461
Publication Date
19780101
Document Type
Book or book chapter
Editors
Waxman-SG
Funding Amount
807725
Funding Type
Grant
Fiscal Year
1978
NTIS Accession No.
NTIS Price
ISBN No.
9780890042151
Identifying No.
Grant-Number-R01-OH-00535
Priority Area
Neurotoxic-effects
Source Name
Physiology and Pathobiology of Axons
State
NY
Performing Organization
Yeshiva University, New York, New York
TOP