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Toxic models of disorders of the peripheral nervous system.

Authors
Schaumburg-HH; Spencer-PS
Source
Neurotoxicology Unit, Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, Bronx, New York 1979 Jan; :1-6
Link
NIOSHTIC No.
00091805
Abstract
Human neuropathies that are analogous to reactions produced in laboratory animals by the administration of exogenous toxins are described. Three kinds of pathological reactions (primarily of the peripheral nervous system) to exogenous toxins are: nerve cell death (toxic neuropathy), primary demyelination (toxic myelinopathy), and axonal degeneration (toxic axonopathy). Peripheral nervous system axonopathies are divided into the common distal central and peripheral type, and the rare proximal type. Pathological reactions are discussed in terms of which nerve part is affected by the toxin, symptoms of pathology, results of animal experimentation with specific toxins, and how these results may affect the study of human neuropathies. The author describes the close relationship between animal studies that provided a valid morphological rationale for toxic distal central and peripheral axonopathies and human toxic reactions.
Keywords
NIOSH-Grant; Neurotoxic-effects; Nervous-system-disorders; Neurotoxicity; Neurotoxins; Laboratory-animals; Neuropathology; Psychological-factors; Peripheral-nervous-system; Physiological-systems; Biochemical-reactions; Chemical-workers; Histopathology; Research-laboratories
Contact
Pathology Albert Einstein Coll of Med 1300 Morris Park Avenue Bronx, N Y 10461
Publication Date
19790101
Document Type
Final Grant Report
Funding Amount
807725
Funding Type
Grant
Fiscal Year
1979
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00535
NIOSH Division
OEP
Priority Area
Neurotoxic Disorders; Neurotoxic-effects
Source Name
Neurotoxicology Unit, Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, Bronx, New York
State
NY
Performing Organization
Yeshiva University, New York, New York
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