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Distal axonopathy: one common type of neurotoxic lesion.

Authors
Spencer-PS; Schaumburg-HH
Source
Environ Health Perspect 1978 Oct; 26:97-105
NIOSHTIC No.
00091750
Abstract
The morphological aspects of neurotoxicity and the principles of testing for the detection of neurotoxic diseases such as distal axonopathies were evaluated. Methodology for establishing normative data for nerve fibers and cells were examined and a listing of toxic chemicals producing structural damage to the nervous system and pathological responses was compiled. Clinical response studies on chronic systemic intoxication of neurotoxic chemicals or drugs were reviewed. A new test for neurotoxicity that is based on the examination of selected areas of brain and nerve tissues was developed. Similarities between neurotoxic pathological expressions and naturally occurring neuropathies associated with human disease and the aging process also were considered.
Keywords
NIOSH-Publication; NIOSH-Grant; Neurotoxic-effects; Laboratory-animals; Neurotoxins; Histopathology; Environmental-contamination; Clinical-studies; Morphology
Contact
Pathology Albert Einstein Coll of Med 1300 Morris Park Avenue Bronx, N Y 10461
CODEN
EVHPAZ
Publication Date
19781001
Document Type
Journal Article
Funding Amount
807725
Funding Type
Grant
Fiscal Year
1979
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00535
ISSN
0091-6765
Priority Area
Neurotoxic Disorders; Neurotoxic-effects
Source Name
Environmental Health Perspectives
State
NY
Performing Organization
Yeshiva University, New York, New York
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