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Cellular Transformations.

Authors
Kuschner-M
Source
NIOSH 1979 Jun:108-110
Link
NIOSHTIC No.
00091707
Abstract
Cellular transformations are discussed in relation to occupational carcinogenesis and experimental medicine. The use of animal models in cancer research, particularly in studies of inhalation cancer, is reviewed. The irritative effects of sulfite (14265453) in carcinoma production are noted, emphasizing the increased incidence of cancer among coke oven operators and workers exposed to roofing tar. Hexavalent-chromium (18540299) as calcium-chromate (13765190) is cited as the source of a 10 fold increase in the incidence of lung cancer in chromate workers. Ionizing radiation from radon and radon daughters is identified as the cause of lung cancer in uranium mine workers. A dose effect for ionizing radiation is shown to be experimentally validated. The effects of industrial byproducts on the general population are reconsidered. The author suggests that the microenvironment created by the individual for himself is a major characteristic in cancer induction.
Keywords
NIOSH-Contract; Contract-210-78-0053; Carcinogenesis; Occupational-health; Epidemiology; Toxic-substances; Cell-alteration; Radiation-effects; Humans; Laboratory-animals;
CAS No.
14265-45-3; 18540-29-9; 13765-19-0;
Publication Date
19790601
Document Type
Conference/Symposia Proceedings;
Funding Type
Contract;
Fiscal Year
1979
NTIS Accession No.
NTIS Price
Identifying No.
Contract-210-78-0053
NIOSH Division
DTS;
Source Name
Occupational Safety and Health Symposia 1978, Division of Technical Services, NIOSH, Cincinnati, Ohio
State
AZ; OH;
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